Tirzepatide 7.5ml
Tirzepatide 15ml
Tirzepatide 30mg/2ml
Tirzepatide is a novel therapeutic agent classified as a Dual Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist. It is often referred to as a "twincretin" because it mimics the action of two natural gut hormones (incretins).
The dual action leads to enhanced metabolic control through several pathways:
- Glucose-Dependent Insulin Secretion: Tirzepatide stimulates the pancreatic beta cells to release insulin only when blood sugar levels are elevated. This effect reduces the risk of severe hypoglycemia when used alone.
- Glucagon Suppression: It reduces the secretion of glucagon (a hormone that raises blood sugar) from the alpha cells of the pancreas, which helps decrease hepatic glucose production.
- Gastric Emptying: It slows down the rate at which food leaves the stomach (gastric emptying). This contributes to a feeling of early and prolonged fullness (satiety).
- Appetite Regulation: By acting on receptors in the brain, it decreases appetite and reduces food intake, leading to significant body weight loss.
Tirzepatide is administered as a subcutaneous injection once weekly.
Step | Dose (mg) | Duration | Purpose |
Initiation | 2.5 mg | 4 weeks | To start treatment and improve tolerability. Note: This dose is not for chronic glycemic control. |
Initial Therapeutic | 5 mg | After 4 weeks of 2.5 mg | The minimum effective therapeutic dose. |
Dose Escalation | 7.5 mg, 10 mg, 12.5 mg, 15 mg | Increase by 2.5 mg increments after at least 4 weeks on the current dose. | To achieve additional glycemic control and/or weight loss. |
Maximum Dose | 15 mg | Once Weekly | The highest recommended dose. |
- Frequency: Once a week, on the same day each week, at any time of the day, with or without meals.
- Injection Sites: Abdomen, thigh, or upper arm. Rotate the injection site each week.
- Missed Dose: If a dose is missed, administer it as soon as possible within 4 days (96 hours) of the missed dose. If more than 4 days have passed, skip the missed dose and resume the regular weekly schedule.
Proper storage is critical to maintain the drug's efficacy.
Storage Condition | Temperature | Key Instructions |
Primary Storage | Refrigerated (2°C to 8°C or 36°F to 46°F) | Store the pen or vial in the original carton to protect it from light. |
Room Temperature | Up to 30°C (86°F) | Can be stored at room temperature for a maximum of 21 days. |
- DO NOT FREEZE. If the medication has been frozen, it must be discarded, even if it has thawed.
- Light Protection: Keep the injection pen/vial in the original carton until ready to use.
- Refrigeration: Once the pen has been stored at room temperature (up to 21 days), it must not be returned to the refrigerator.
