Retatrutide 5mg
Retatrutide 10mg
Retatrutide 20mg
Retatrutide is often referred to as a triple-hormone-receptor agonist because it targets and activates three distinct incretin and metabolic hormone receptors simultaneously:
- GLP-1 Receptor (Glucagon-Like Peptide-1)
- GIP Receptor (Glucose-Dependent Insulinotropic Polypeptide)
- Glucagon Receptor (GCGR)
This triple action is what sets it apart from existing medications like semaglutide (which is a single GLP-1 agonist) and tirzepatide (which is a dual GLP-1/GIP agonist).
Receptor | Primary Effect | Contribution to Weight Loss |
GLP-1 | Slows gastric emptying, increases satiety (feeling full), and stimulates glucose-dependent insulin release. | Reduces Appetite and Calorie Intake. |
GIP | Enhances insulin secretion in a glucose-dependent manner and plays a role in regulating fat metabolism. | Improves Glucose Control and complements appetite suppression. |
Glucagon | Increases energy expenditure (calorie burning) and promotes the breakdown of stored fat (lipolysis). | Increases Metabolism and Fat Burning. |
The results from the Phase 2 clinical trials have been exceptionally promising:
- Weight Loss: Participants with obesity (without diabetes) receiving the highest dose ($12\text{ mg}$) achieved a mean weight reduction of $24.2\%$ over 48 weeks. This level of weight loss is one of the highest reported for a pharmacological intervention to date.
- Metabolic Improvement: The drug demonstrated significant improvements in various cardiometabolic markers, including reductions in blood pressure, cholesterol levels, and blood glucose ($\text{HbA1c}$).
- Liver Health: Retatrutide showed substantial reduction in liver fat content, suggesting potential benefits for treating metabolic dysfunction-associated steatotic liver disease (MASLD/NAFLD).
Similar to other drugs in this class, the most common side effects are primarily gastrointestinal and are typically mild to moderate in severity, often occurring during the dose escalation phase:
- Nausea
- Diarrhea
- Vomiting
- Constipation
In some trials, a dose-dependent increase in heart rate was observed, which usually peaked around 24 weeks and then began to decline.
Retatrutide is considered a potential game-changer in the treatment of obesity and related metabolic diseases due to its triple-agonist mechanism and superior weight loss results in early trials. However, it is still an experimental drug and is not yet approved for clinical use.
Retatrutide is administered as a once-weekly subcutaneous injection.4 To minimize gastrointestinal side effects (like nausea and vomiting), the dose is gradually increased over several weeks, a process called titration.5
1. Dosing Range Studied
Clinical trials have tested several weekly maintenance doses:6
- Lowest Dose: 7$1\text{ mg}$ per week8
- Target Maintenance Doses: 9$4\text{ mg}$, 10$8\text{ mg}$, and 11$12\text{ mg}$ per week12
- Highest Dose Tested: 13$12\text{ mg}$ per week (This dose resulted in the most significant weight loss: mean 14$\sim 24.2\%$ body weight reduction at 48 weeks).15
2. Standard Titration Schedule
The process involves starting low and increasing the dose every four weeks, depending on the individual's tolerance.16
Phase | Weeks | Weekly Dose (mg) | Purpose |
Starting Dose | Weeks 1–4 | $1\text{ mg}$ or $2\text{ mg}$ | Allows the body to adjust and minimizes initial side effects. |
Escalation | Weeks 5–8 | $4\text{ mg}$ | Early therapeutic effects begin; appetite suppression increases. |
Further Escalation | Weeks 9–12 | $8\text{ mg}$ | A common maintenance dose with significant weight loss results. |
Highest Dose | Weeks 13+ | $12\text{ mg}$ | The maximum dose tested, associated with the highest weight loss. |
3. Maintenance Dose
The final maintenance dose (the dose taken long-term) is expected to be between 17$8\text{ mg}$ and 18$12\text{ mg}$ once weekly, determined by the patient's individual response, weight loss goals, and tolerance to side effects.19
The final approved dosage schedule will be determined by the results of the ongoing Phase 3 trials and the FDA/regulatory review process.20 For now, the most effective weekly dose shown in studies is 21$12\text{ mg}$, reached through a slow, stepwise titration from a lower starting dose
Storage Option Temperature Maximum Time Limit Preferred In the Refrigerator ($2^{\circ}C$ to $8^{\circ}C$)Until the Expiration Date (as long as it hasn't been out of the fridge for too long).
